Influence of Reward on Corticospinal Excitability during Movement Preparation

Abstract

Current models of decision making postulate that action selection entails a competition within motor-related areas. According to this view, during action selection, motor activity should integrate cognitive information (e.g., reward) that drives our decisions. We tested this hypothesis in humans by measuring motor-evoked potentials (MEPs) in a left finger muscle during motor preparation in a hand selection task, in which subjects performed left or right key presses according to an imperative signal. This signal was either obvious or ambiguous, but subjects were always asked to react as fast as possible. When the signal was really indistinct, any key press was regarded as correct, so subjects could respond "at random" in those trials. A score based on reaction times was provided after each correct response, and subjects were told they would receive a monetary reward proportional to their final score. Importantly, the scores were either equitable for both hands or favored implicitly left responses (reward(neutral) and reward(biased) blocks, respectively). We found that subjects selected their left hand more often in the reward(biased) than in the reward(neutral) condition, particularly after ambiguous signals. Moreover, left MEPs were larger, as soon as the signal appeared, in the reward(biased) than in the reward(neutral) conditions. During the course of motor preparation, this effect became strongest following ambiguous signals, a condition in which subjects' choices relied strongly on the reward. These results indicate that motor activity is shaped by a cognitive variable that drives our choices, possibly in the context of a competition taking place within motor-related areas.