Abstract

目的 探讨注射器死腔残留量对卡介苗接种免疫效果的影响.方法 采取随机抽样的研究方法,将正常新生儿分成3组,对照组278例,实验1组325例,实验2组300例,用改变菌液浓度或预抽注射器死腔残留量来减少卡介苗残留量,保证接种的卡介苗量.具体为对照组每支卡介苗溶解稀释时用0.5 ml注射用水配制,取0.1 ml菌液接种,每支卡介苗接种5人;实验1组每支卡介苗溶解稀释时用0.5 ml注射用水配制,取0.125 ml菌液接种,每支卡介苗接种4人;实验2组每支卡介苗溶解稀释时用0.75 ml注射用水配制,取0.15 ml菌液接种,每支卡介苗接种5人.将3组新生儿卡介苗接种免疫效果进行比较.结果 实验组卡介苗阳转率及卡疤成功率明显高于对照组(P<0.05).结论 本研究实验组的方法保证了新生儿卡介苗接种的菌苗有效量,从而提高了卡介苗接种后PPD的阳转率及卡疤成功率,临床上配制溶解稀释卡介苗和接种卡介苗时应考虑注射器死腔残留的问题。

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