Abstract
Multiple primary malignancies (MPM) have become increasingly prevalent worldwide. This investigation was aimed at establishing the clinicopathological characteristics of MPM patients and evaluating the impact of the living environment on MPM in the Taiwanese population. From January 2009 to December 2013, a total of 8,268 cancer patients were identified in our institutional center. Of these, 125 were diagnosed as MPM and thus enrolled. Data for clinicopathological features and treatment approaches for these MPM patients living in urban or suburb zone were obtained. Findings for the air pollution status in Taiwan were also collected. The most common cancer match of MPM was esophageal cancer with hypopharyngeal cancer (12.8%), followed by colorectal cancer with gastric cancer (6.4%) and colorectal cancer with breast cancer (5.6%). The air quality was significantly worse in the urban than in the suburban zone and there was a remarkably higher portion of MPM patients in the urban zone suffering from grade III and IV post-chemotherapeutic neutropenia (30.8% vs 15.1%, P=0.036). The tumor frequency and site distribution should be taken into the clinical evaluation because there is a relatively high risk of developing MPM. This study also highlighted the potential influence of environmental factors on post-chemotherapeutic neutropenia for patients with MPM.
Highlights
The prevalence of multiple primary malignancies (MPM) has been rising worldwide, according to advancing medical management of chronic diseases and subsequently the increasing life span
A significantly higher portion of Multiple primary malignancies (MPM) patients living in urban zone had HTN than those living in suburb zone (53.8% vs 27.4%, P=0.003)
Our main finding in the present study indicated the most frequent tumor site distribution in patients with MPM was malignancies in upper aerodigestive tract, subsequently colorectal cancer, hepatocellular carcinoma, gynecological cancers and gastric cancer
Summary
The prevalence of multiple primary malignancies (MPM) has been rising worldwide, according to advancing medical management of chronic diseases and subsequently the increasing life span. To present, it was reported the incidence of MPM varied from 0.7% to 18% in all cancer patients, owing to different populations (Luciani et al, 2009; Gursel et al, 2011; Travis et al, 2013). Multiple primary malignancies (MPM) have become increasingly prevalent worldwide This investigation was aimed at establishing the clinicopathological characteristics of MPM patients and evaluating the impact of the living environment on MPM in the Taiwanese population.
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