Influence of reserve antimicrobial indent form in antimicrobial utilization pattern in intensive care unit of tertiary care hospital in North India

Abstract

Background: Misuse and overuse of antimicrobials in intensive care units is of particular concern as it creates selective evolutionary pressure and thereby enables antimicrobial resistant bacteria to increase rapidly resulting in loss of antimicrobial effectiveness. The aim of the present study was to evaluate influence of Reserve Antimicrobial Indent form in Strengthening the antimicrobial stewardship in intensive care unit of tertiary care hospital, Rajasthan. Methods: An observational study was conducted over a period of 18 months, and the data was obtained from MRD and from the ICU after introduction of reserve antimicrobial indent form, of a tertiary care hospital. All the data was tabulated in summery sheets and were analyzed by using computer software SPSS version 20 and Microsoft Excel 2019. Results: A total 257 cases were reviewed during the study period, among these 46.77% were males and 53.23% were females in MRD group, out of 124 cases and 53.38% were males and 46.62% were females in MICU group, out of 133 cases. Total number of reserve drug prescribed was 444 out of which in MRD group Amoxicillin /Clavulanic acid were commonly prescribed followed by piperacillin/tazobactumand in ICU group Meropenem were commonly prescribed followed by piperacillin/tazobactum. Conclusions: Study showed reducing trend in overall consumption of reserve antimicrobial drugs, which also gave an overview of antimicrobial consumption pattern in intensive care unit.