Abstract

This chapter studies the influence of radiofrequency electromagnetic radiation in short-wave range of 0.99, 1.41, 1.84, 2.92, 5.09, 7.41, and 42.0 MHz on the magnetic properties of magneto-mechanochemically synthesized (MMCS) antitumor nanocomplex comprising iron oxide nanoparticles and antitumor anthracycline antibiotic doxorubicin. The methods of magnetometry and electron spin resonance (ESR) spectra were used. In experiments with MMCS antitumor nanocomplex, it was found positive correlation between the area of hysteresis loop and electromagnetic field (EMF) frequency and negative correlation between ESR relative intensity and EMF frequency. Magnetic properties of nanocomplex can be interpreted by well-known nonthermal physical effects of eddy current on magnetic resonance in nanostructures. The skin depth depends on EMF frequency. The ESR results agree with well-known fact, that product yield in free radical reaction oscillates with EMF frequency. The interpretation of experimental data on correlation between the frequency (energy) of EMF radiation and magnetic properties of MMCS nanocomplex and concentration of paramagnetic centers in its structure can contribute to personalized treatment of cancer patients.

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