Abstract
The purpose of this study was to evaluate the endometrial acid and alkaline phosphatase activity in rhesus monkeys chronically treated for 24 months with 3 levels of quinestrol (17-ethynlestradiol cyclopentyl ether). The 3 levels were: 1) 4 animals, 4 mcg/kg;2) 3 animals, 20mcg/kg; 3) 4 animals 100 mcg/kg. There were 4 animals included as sesame oil controls. All monkeys receiving quinestrol had some degree of cystic endometrial hyperplasia, dose-related, ranging from trace, to weak, to moderate cystic endometrial hyperplasia for high dose animals. The treated monkeys also showed thickening of the glandular basement membrane and an increase in endometrial and myometrial collagen (fibrosis), also apparently dose-related. In the monkeys receiving quinestrol, glandular alkaline phosphatase activity was comparable to that of the follicular and early luteal animals while the acid enzyme activity resembled that found in early and late luteal controls. Frequency of menstrual cycles was reduced.
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