Influence of Protein Adsorption onto Titanium Surfaces on Osteoblasts Cell Activity

Abstract

Protein adsorption occurs immediately following implantation of a biomaterial, and it is widely assumed that this will have an influence on the subsequent cellular response.1 Despite numerous studies, there are still questions on the degree of influence that this process has on initial cellular events, particularly when the surface exhibits topography.2 To investigate this question, we have compared the osteoblastic cell growth onto polished and nanoporous titanium and glass as control by modulating the exposure to serum proteins during the initial phase of cell culture.