Abstract
Uterine cervical tissue was obtained from pregnant women undergoing abortion of caesarean section. The tissue was incubated in Krebs-Ringer bicarbonate buffer containing prostaglandin (PG) E 2 and radioactive precursors for collagen ( 3H proline) and proteoglycans ( 3H glucosamine). After incubation the tissue-bond radioactivity was determined and related to the tissue dry weight. The effect of PGE 2 on te net tissue radiolabelling varied with the gestational age and with the cervical status at operation. In early 1st trimester PGE 2 increased the labelling with 3H proline but decreased that with 3H glucosamine. From the 12th week of gestation until term pregnancy conditions were reversed, i.e. the incorporation of 3H proline was reduced and that of 3H glucosamine was augmented following treatment with PGE 2. After start of labour and rupture of the membrane, however, PGE 2 diminished the labelling with 3H proline as well as 3H glucosamine. It is suggested that PGE 2 is a modulator of biochemical events which underlie cervical ripening.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
