Abstract
Mangostin (Garcinia mangostana L.) fruit pericarp (GMP) extract has been shown to have antimicrobial and antioxidant activities. This study aimed to formulate and evaluate gel formulations of GMP extract using sodium carboxymethylcellulose as a gelling agent and propylene glycol (PG) in varying concentrations (i.e. 0-40%). GMP extract was evaluated for total mangostin content and antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. Physical gel characteristics were also examined. All gels had similar pH and spreadability, however, gel with 40% PG produced significantly lower viscosity. Antibacterial activities against S.aureus were shown to be the same among GMP extract gels. The antioxidant activity of all GMP extract gels could be confirmed based on the radical DPPH scavenging method. PG content of 40% significantly reduced the increase of GMP extract gel viscosity after being stored for four weeks at room temperature. Additionally, the lowest syneresis was also shown for GMP extract gel with 40% PG content.
Highlights
Topical products that promote healthy skin have been explored and developed continuously
This research aimed to formulate Garcinia Mangostana Pericarp (GMP) extract gel using Na CMC as the gelling agent and to evaluate the influence of gel composition varying in propylene glycol (PG) concentrations
This result is in agreement with Arellano et al (1999) who found that PG concentration in the gel up to 30% did not result in significant changes in viscosity
Summary
Topical products that promote healthy skin have been explored and developed continuously. Studies documented that polyphenols have remarkable antimicrobial and antioxidant activities. High polyphenols content can be found, for example, in some of the fruit peel such as pericarp of mangostin (Garcinia mangostana L.) fruit. It has been used traditionally mostly in the Southeast Asia region for skin infection and wound therapy (Obolskiy et al, 2009). The pericarp of mangostin fruit has a high content of xanthones, a class of polyphenolic compound, which posses many pharmacological activities including antimicrobial and antioxidant (Obolskiy et al, 2009, Suttirak and Manurakchinakorn, 2014)
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