Abstract
To observe the influence of propofol, isoflurane and enflurance on interleukin-8 (IL-8) and IL-10 levels in cancer patients. Ninety cancer patients with selective operation from March 2011 to May 2014 were randomly divided into group A (34 cases), group B (28 cases) and group C (28 cases). Intramuscular injections of scopine hydrochloride and phenobarbital sodium were routinely conducted to 3 groups. After general anesthesia was induced, tracheal intubations were given. During the maintenance of anesthesia, 0.5~1.0 mg/ kg propofol was intravenously injected to group A discontinuously, while continuous suctions of isoflurane and enflurance were subsequently performed to group B and C correspondingly. Clinical outcomes, postoperative complications as well as serum IL-8 and IL-10 levels before operation (T0), at the time of skin incision (T1), 3 h after the beginning of the operation (T2) and 24 h (T3) and 72 h (T4) after the operation were observed among 3 groups. Operations in all groups were successfully completed. The rates of surgery associated complications were 8.82% (3/34), 7.14% (2/28) and 7.14% (2/28) in group A, B and C, respectively, and there were no significant differences (P>0.05). Serum IL-8 and IL-10 levels increased gradually from the beginning of the operation and reached the peak at T3, and were evidently higher at each time point than at T0 (P<0.01). At T1, serum IL-8 and IL-10 levels had no significant differences among 3 groups (P<0.05), but the differences were significant at T2, T3 and T4 (P<0.05). Moreover, correlation analysis suggested that serum IL-8 level was in positive relation with IL-10 level (r=0.952, P<0.01). Propofol, which is better in inhibiting serum IL-8 secretion and improving IL-10 secretion than isoflurane and enflurance, can be regarded as a preferable anesthetic agent in inhibiting traumatic inflammatory responses.
Highlights
Pro-inflammatory cytokine and anti-inflammatory cytokine, maintaining a certain balance in healthy population, often expressed disorderly in cancer patients, and the surgery induced traumatic inflammation could aggravate their imbalance and disorder (Ziebell et al, 2010; Jawa et al, 2011; Marik et al, 2012)
At T1, serum IL-8 and IL-10 levels had no significant differences among 3 groups (P>0.05), but the differences were significant at T2, T3 and T4 (P
The levels of serum IL-8 and IL-10 had no significant difference among 3 groups before the operation (P>0.05)
Summary
Pro-inflammatory cytokine and anti-inflammatory cytokine, maintaining a certain balance in healthy population, often expressed disorderly in cancer patients, and the surgery induced traumatic inflammation could aggravate their imbalance and disorder (Ziebell et al, 2010; Jawa et al, 2011; Marik et al, 2012). Studies have shown that anesthetic agents have certain impact on the secretion of isolated cytokine, but their effects on the expressions of isolated cytokine in vivo are still controversial (Hofstetter et al, 2005; Ward et al, 2011; Mawhinney et al, 2012). This study mainly observed the influence of propofol, isoflurane and enflurance on the expressions of interleukin-8 (IL-8) and IL-10 in cancer patients
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