Abstract

目的 通过对深部真菌感染高危患者体内分离的念珠菌进行体外药敏试验,了解氟康唑预防用药对其药物敏感性的影响.方法 采用微量稀释法测定152株分离自血液科、重症监护病房和老年科病房住院患者的痰、尿、便和支气管灌洗液的念珠菌对氟康唑的敏感性.对氟康唑预防用药组和未预防用药组两组念珠菌对氟康唑的敏感性差异进行统计学分析.结果 93.4%(142/152)的念珠菌对氟康唑敏感.氟康唑预防用药组和非预防用药组非白念珠菌分离率分别为41.4%(12/29)和25.3%(21/83),两者相比,差异无统计学意义(χ=2.67,P>0.05).氟康唑预防用药组和非预防用药组MIC>8 μg/ml的菌株数分别为7株(24.1%)和3株(3.6%),两者相比,差异有统计学意义(χ2=8.75,P<0.05).氟康唑预防用药会导致念珠菌MIC值的提高.结论 从深部真菌感染高危患者体内分离的大部分念珠菌菌株对氟康唑敏感.氟康唑预防用药可能会导致对氟康唑不敏感的念珠菌菌株感染的出现。

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.