Abstract

Total collagen and its soluble fraction as well as water content were determined in late pregnancy in the uterine cervix in a population of 36 rats treated with progesterone (n = 10), mifepristone (n = 13) and controls (n = 13). In both treated groups there were no signs of delivery on the 21st day of gestation. Water content was significantly lower in the mifepristone-treated group. A statistically higher soluble collagen fraction was observed in this group. The results obtained in the progesterone-treated group were not significantly different when compared to the controls. Significant differences were observed between progesterone- and mifepristone-treated groups in total and soluble fractions of collagen.

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