Abstract
In order to interpret the known lipoprotein changes in probucol-treated patients, serum concentrations of apolipoproteins (A-I, A-II, B, C-II, C-III, E) were measured before, during and after probucol administration (2 × 500 mg p.d.), in 16 healthy males (30.3 ± 5.6 years old). Cholesterol concentrations were determined in LDL and VLDL fractions as well as in HDL subfractions which were isolated by preparative ultracentrifugation. In addition, apolipoprotein A-I and A-II concentrations were measured in the HDL subfractions. Compared with the baseline values, significant apolipoprotein changes were found in the serum apolipoprotein A-I (151 ± 18 to 115 ± 31 mg/dl; P < 0.001) and C-II levels during administration. The HDL subfraction analysis showed that the decrease of HDL-cholesterol and apolipoprotein A-I (59.9 ± 23.5 to 34.4 ± 16.4 mg/dl, P < 0.001, and 65.7 ± 49.0 to 37.5 ± 23.5 mg/dl, P < 0.05, respectively) was predominantly related to the HDL 2b subfraction ( d= 1.063−1.100 rg/ml)
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