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Abstract
The clarification of the molecular mechanisms of the effect of a plant adaptogen’s active substance is a topical study direction. In the present work, we studied the effect of phytopreparations containing the Serratula coronata L. phytoecdysteroids (20-hydroxyecdysone and inocosterone) or the Trigonella foenumgraecum L. steroid glycosides (dioscin and protodioscin) on the expression of stress-response genes, stress resistance, and the life span of the Drosophila melanogaster. It was demonstrated that phytopreparations activate the mechanisms of antioxidant protection (Sod1), but reduce the level of induction of DNA repair (XPF and Rad51) and the apoptosis (Hid) genes. At the same time, the studied phytopreparations have a moderate adaptogenic and geroprotective effects associated with activation of the hormesis mechanisms.
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