Influence of Preemptive Intravenous Ibuprofen on Post-Operative Pain and Opioid Consumption after Laparoscopic Cholecystectomy

Abstract

Abstract Background cholecystectomy is the most common abdominal surgical procedure in developed countries, and is generally performed laparoscopically. Laparoscopic cholecystectomy is regarded as the gold standard surgical technique for gallstone diseases. This procedure results in less postoperative pain, a better cosmetic outcome, shorter hospitalization faster healing, and earlier mobilization than open cholecystectomy. Aim of the Work the purpose of this study is to investigate the effects of a single preemptive dose of IV ibuprofen on postoperative pain and opioid consumption in patients undergoing laparoscopic cholecystectomy. Patients and Methods this study will be a prospective study on patients who are scheduled for laparoscopic cholecystectomy will be informed about the different components of postoperative pain they would experience, and they will be selected by the same investigator for their ability to differentiate these pain components and to use the visual analog scale. After approval of the local ethics committee. Results this study showed that a single preemptive dose of IV ibuprofen reduced 24-hour opioid consumption and was effective in the emergence of lower pain scores in the postoperative period. In addition, IV ibuprofen significantly reduced rescue analgesic use. In addition IV ibuprofen has played a key role with opioid sparing effect. Conclusion a single preemptive dose of 400 mg resulted in better pain scores by reducing postoperative opioid use in the 1st 24 hours in patients undergoing laparoscopic cholecystectomy by 45%. It also reduced rescue analgesic use in the postoperative period and opioid-related side-effects such as nausea-vomiting.