Abstract

The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of cells during microbubble flows. An optimized Prony-Dirichlet series was used to model the cells' power-law rheology (PLR) and results were compared with a Maxwell fluid model. Results indicate that membrane strain and the risk for cell injury decreases with increasing channel height and bubble speed. In addition, the Maxwell and PLR models both indicate that increased viscous damping results in less cellular deformation/injury. However, only the PLR model was consistent with the experimental observation that cell injury is not a function of stress exposure duration. Correlation of our models with experimental observations therefore highlights the importance of using PLR in computational models of cell mechanics/deformation. These computational models also indicate that altering the cell's viscoelastic properties may be a clinically relevant way to mitigate microbubble-induced cell injury.

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