Abstract
1. The influence of KCl and CaCl2 on the inhibition of the catalytic activity of butyrylcholinesterase (BuCE) and acetylcholinesterase (ACE) by cationic organophosphorus inhibitors with combined action and with a reversible type of inhibition was investigated at 25‡, pH 7.5, and ionic strength (Μ) 0.0044, 0.11, and 0.55. Increasing Μ reduces irreversible and reversible inhibition. 2. In the case of the same increase in Μ, the influence of KCl on the values of the inhibitor constants, as a rule, was substantially greater than the influence of CaCl2; ACE proved to be more sensitive to a change in Μ than BuCE. The presence of specific salt effects in the reactions of cholinesterases was demonstrated.
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