Abstract
The influence of posture and diurnal rhythm on the renal excretion of acid was examined in 4 normal and 2 adrenalectomized subjects. Assumption of the recumbent position in normal subjects resulted in inhibition of acid excretion, the extent of inhibition being influenced by the diurnal rhythm. Postural inhibition of acid excretion was also observed at high levels of acid excretion following methionine loading. In adrenalectomized subjects assumption of the recumbent position resulted in postural natriuresis but not in any decrease in acid excretion. The postural inhibition of acid excretion occurring in normal subjects could not be restored in adrenalectomized subjects by administration of hydrocortisone, methylprednisolone or aldosterone. It is suggested that (1) postural inhibition of acid excretion is dependent on adrenal function but not directly on the presence of glucocorticoid hormone or aldosterone, (2) that the mechanism of postural and diurnal variations in acid excretion may share a common factor.
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