Influence of postoperative radiation therapy timing and dose for Wilms' tumor

Abstract

Prompt postoperative radiation therapy given within hours, and the use of higher doses for older children have been thought important by some therapists for success in the treatment of children with Wilms' tumors. These factors were analyzed in relation to local and distant relapse rates for 242 Wilms' tumor patients given postoperative irradiation. All also received actinomycin-D, vincristine, or both. Patients given less than specified rad doses modulated for age fared as well as those receiving at least the target dose. Sample target doses recommended in the Study were 1800 rads for babies and 4000 rads for children four or more years of age.