Abstract
Arachidonic acid (ARA), an omega-6 (ω-6) polyunsaturated fatty acid (PUFA), is involved in the development and maintenance of renal functions, whereas docosahexaenoic acid (DHA) is an omega-3 (ω-3) PUFA that has anti-inflammatory effects and attenuates nephropathy. However, their effects on the progression of chronic kidney disease (CKD) remain unknown. The aim of this study was to assess the effects of feeding ARA, DHA, and ARA and DHA-containing diets on rats with 5/6 nephrectomized kidneys. Urine and feces were collected every 4 weeks, and the kidneys were collected at 16 weeks after surgery. Urinary albumin (U-ALB) excretion increased gradually with nephrectomy, but the U-ALB excretion was attenuated by feeding the rats with an ARA + DHA-containing diet. Reactive oxygen species (ROS) levels in the kidneys were lower in the ARA + DHA group than in the other groups. At 4 weeks after surgery, the lipid peroxide (LPO) levels in the plasma of the ARA + DHA groups decreased significantly after surgery compared to the control CKD group, but this did not happen at 16 weeks post-surgery. There was a significant negative correlation between LPO levels in the plasma at 4 weeks and creatinine clearance, and a positive correlation with urinary albumin levels. These results suggest that the combination of ARA and DHA inhibit the progress of early stage CKD.
Highlights
The kidneys play an important role in the homeostasis of body fluids, regulation of blood pressure, production of red blood cells, and in maintaining bones strength.Blood pressure increases with age
Nephrectomy did not affect the body weight of rats, as there were no significant differences among the five groups
The results of our study showed that the levels of Reactive Oxygen Species (ROS) and ONOO− in the kidney decreased with the intake of Arachidonic acid (ARA) and docosahexaenoic acid (DHA) at 16 weeks after nephrectomy (Figures 7 and 8)
Summary
The kidneys play an important role in the homeostasis of body fluids (the balance of water, salts, and minerals such as sodium, calcium, phosphorus, and potassium in the blood), regulation of blood pressure, production of red blood cells, and in maintaining bones strength. Salt, and sodium concentration in the body increases due to decreased kidney functions, resulting in increased blood pressure. The blood volume increases and the blood vessels become hard or clogged, making them more susceptible to arteriosclerosis [1]. The number of glomeruli decreases with age, resulting in a decreased glomerular filtration rate (GFR).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
