Influence of polyaminocarboxylic acids on the removal of manganese-54 from the body organs of sham-operated and partially hepatectomized rats

Abstract

EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N, N, N′, N′-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54 ( 54Mn) from some organs of sham-operated and partially hepatectomized rats in early manganese (Mn) poisoning. CDTA was found to be most effective in removing 54Mn from the liver of both sham-operated and hepatectomized rats. These chelating agents also lowered the Mn levels in kidney, spleen and brain of poisoned rats. Although a significantly higher accumulation of Mn was observed in hepatectomized rats, there was no significant difference in the efficiency of the chelating agents in removing Mn from the body organs of poisoned animals of both the sham-operated and hepatectomized groups. An attempt has been made to seek a possible correlation between % removal of Mn by various polyaminocarboxylic acids and their corresponding stability constants.