Abstract
ABSTRACT The effect of pituitary stalk section on growth hormone secretion, insulin secretion and carbohydrate tolerance was studied in 13 women with advanced metastatic breast cancer. Plasma immunoreactive growth hormone concentrations were measured during standard insulin tolerance tests in 8 women preoperatively and 12 women postoperatively. Glucose disappearance rates (Kg), plasma growth hormone and insulin concentrations were measured after the rapid intravenous administration of glucose in 5 women preoperatively and 9 women postoperatively. In addition, the acute effect of stalk section on thyroidal discharge rate was studied in one patient. Measurable growth hormone levels in the fasting state were found on one or more occasions in 4 out of 8 patients studied during the early postoperative period. None of the 5 patients studied 8 months or longer after surgery had detectable levels of growth hormone under basal conditions. Peak preoperative growth hormone responses to insulin were between 22 and 11...
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