Abstract
Abstract Objective This study was performed to investigate the physical symptoms potentially affecting distress in patients with advanced and recurrent colorectal cancer and to consider nursing care for these patients. Methods A self-administered questionnaire survey was given to patients with advanced and recurrent colorectal cancer undergoing outpatient chemotherapy in five hospitals. All outpatients met the study criteria and provided informed consent. The questionnaire included sociodemographic information and the Japanese version of the M. D. Anderson Symptom Inventory (MDASI-J). The items of distress on the MDASI-J were dependent variables, and the 11 symptom items were independent variables. Stepwise multiple regression was conducted using SPSS ver.25. Results Responses were received from 76 patients (response rate: 95.0%). The patients’ mean age was 66.5 ± SD8.5 years, and 50 (65.8%) were male. Sixty-seven (88.2%) patients were undergoing surgery, and the median treatment period after relapse or metastasis was 12.0 (0-114) months. The mean MDASI-J score was 3.7 ± 3.0 for numbness or tingling, 3.0 ± 2.6 for fatigue, and 2.7 ± 2.6 for drowsiness. Physical symptoms that affected the MDASI-J distress score were numbness or tingling, dry mouth, and lack of appetite (R2= 0.48, p Discussion and Implication About half of the distress in patients with advanced and recurrent colorectal cancer was explained by symptoms of numbness or tingling, dry mouth, and lack of appetite. We believe that the symptoms resulting in distress in patients with advanced and recurrent colorectal cancer were closely related to daily life, such as activities of daily living and meals. These findings suggest that medical staff should support the management of symptoms affecting activities of daily living, such as patients’ activities and meals, to help reduce distress in patients with advanced and recurrent colorectal cancer. This work was supported by KAKENHI Grant Number A16H055760.
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