Abstract
The influence of pertussis toxin (PTX) on thermic responses elicited by morphine and neurotensin was evaluated in unrestrained rats kept at 22°C. High doses of morphine (9–36 μg/rat i.c.v.) lowered body temperature and low doses (1.25. 2.5 μg/rat i.c.v.) produced hyperthermia. The hyperthermic effect was more resistant than the hypothermie effect to naloxone antagonism. Neurotensin (50, KM)μg/rat i.c.v.) induced marked hypothermia followed by hyperthermia. I.c.v. injection of PTX (1 μg), six days before morphine (18 μg/rat i.c.v.). replaced the opiate hypothermia by consistent hyperthermia and reduced by 60% the hyperlhermia elicited by morphine (2.5 μg/rat i.c.v.). The toxin also affected the thermic responses induced by neurotensin (50 μg/rat i.c.v.) administered six days after PTX (1 μg/rat i.c.v.). The initial hypothermia was enhanced by 173% and the late hypcrthermia was fully antagonized. It thus appears that PTX-scnsitivc G-protcins play different roles in the molecular events underlying the thcrmoregulatory responses to morphine and neurotensin.
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