Abstract
Objective To explore the effect of periodontal foundation treatment on serum interleu- kin （IL） -6 and leptin levels in patients with chronic periodontitis and type 2 diabetes mellitus. Methods Thirty-four patients with chronic periodontitis and type 2 diabetes mellitus admitted to our hospital from June 2010 to Feb. 2012 served as observation group, and 34 patients with chronic periodontitis alone as control group. All patients were given periodontal foundation treatment. Parameters including bleeding on probing （BOP）, probing depth （PD）, attachment loss （AL）, and serum levels of IL-6 and leptin were measured before and after treatment, and compared between the two groups. Results Before treatment, the serum levels of IL-6 and leptin in observation group were （3.42 ±0. 31 ） and （ 1.24 ± 1.13） p,g/L, which were significantly higher than those in control group （ P 〈 0. 05 ）. After treatment for three months, BOP, PD, AL and serum levels of IL-6 and leptin were significantly lower than those before the treatment in two groups [（ 3. 12± 0. 34）, （ 1.01 ±0. 50 ） ug/L] （ P 〈 0. 05 ）. Conclusion The periodontal foun- dation treatment can effectively improve periodontal status and decrease the serum levels of IL-6 and leptin in patients with chronic periodontitis and type 2 diabetes mellitus. Key words: Periodontal treatment; Type 2 diabetes mellitus; Interleukin-6; Leptin
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