Influence of peak impact force magnitude and symmetry on the progression from unilateral to bilateral knee pain: the most study

Abstract

Purpose: In many cases, knee OA begins as unilateral disease with pain in only one knee; yet, up to 90% of individuals with unilateral knee OA develop bilateral knee OA within 10 years. This high incidence is concerning because bilateral knee OA is associated with greater functional decline, worse pain, and lower quality of life compared to unilateral knee OA. To this end, a critical need exists to determine why knee OA commonly progresses from unilateral to bilateral disease. Increased loading is a well-established risk factor for knee OA development and progression.