Abstract
Large air cavity is commonly seen in the radiation therapy treatment planning of head and neck cancer. It is often unclear how much cavity should be included in PTV definition for planning and its consequence on delivered dose with the presence of patient setup uncertainty. The aim of this study is 1) determine if three different methods of PTV delineation at an air cavity interface yield differences in overall tomotherapy plan quality and treatment efficiency, and 2) analyze how patient setup uncertainty affects the delivered dose for these three target definitions.
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