Influence of particle size of nano zinc oxide on the controlled delivery of Amoxicillin

L Palanikumar,C Balachandran,S Ramasamy,G Hariharan

doi:10.1007/s13204-012-0141-5

L Palanikumar, C Balachandran + Show 2 more

Open Access

https://doi.org/10.1007/s13204-012-0141-5

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Journal: Applied nanoscience	Publication Date: Jul 5, 2012
Citations: 49	License type: cc-by

Affiliation: Anna University, Chennai

Abstract

A great effort has been exerted to develop drug carriers aiming at satisfying the requirements, such as safety, greater efficiency, predictable therapeutic response, and prolonged release period. The present study aims at developing the use of zinc oxide nanoparticles as a carrier as a function of particle size for amoxicillin drug delivery system. The amoxicillin-loaded zinc oxide nanoparticles have a good antibacterial activity against infectious Gram-positive and Gram-negative bacteria. Zinc oxide nanoparticles have been prepared by wet chemical precipitation method varying the pH values. Particle size and morphology of the as-prepared ZnO powders are characterized by X-ray diffraction, Fourier transform infrared spectroscopy and transmission electron microscope. Drug loading, in vitro drug release and antibacterial activity have been analyzed. Maximum zone of inhibition is observed for Staphylococcus epidermis. The results show that inhibitory efficacy of drug-loaded ZnO nanoparticles is very much dependent on its chosen concentration, drug loading, and size.

Highlights

Over the past few years, local delivery systems have attracted much attention due to their efficacy to improve the ingrowth and regeneration of bones and teeth (Kim et al 2004)
The XRD pattern of synthesized zinc oxide (ZnO) nanoparticles demonstrated that the nano ZnO to be crystalline in nature, and the diffraction peaks matched very well with hexagonal zincite phase of ZnO (Fig. 1)
A drug delivery system with different sizes of ZnO NPs has been developed to treat against infectious bacteria

Summary

Introduction

Over the past few years, local delivery systems have attracted much attention due to their efficacy to improve the ingrowth and regeneration of bones and teeth (Kim et al 2004). The advances in micro and nanofabrication technology have enhanced the tools available to create clinically important therapeutic applications (Lu and Chen 2004)

Methods

Results

Conclusion