Influence of paroxetine combined with Chaihuxiaoyao mixture on life quality of patients with depression

Abstract

Objective: To evaluate the influence of Chaihuxiaoyao mixture(CXM) on life quality of patients with depression.Methods: One hundred and ninety patients with depression were randomly divided into paroxetine combined with CXM group(trial group) and paroxetine combined with placebo group(control group).The doses of CXM and placebo were 50 ml,bid.The initial dose and recommended dose of paroxetine were 20 mg/d,and the highest dose was 40 mg/d.All of the patients had a 8-week treatment.The therapeutic efficacy was evaluated before and after the treatment by Hamilton depression rating scale(HAMD) and the short form-36 health survey(SF-36),and the adverse drug reactions(ADRs) were evaluated by treatment emergent symptom scale(TESS).Results: One hundred and eighty-two patients completed the trial,89 cases in trial group and 93 cases in control group.Compared with the baseline,significant differences in HAMD scores and the SF-36 scores were observed in both groups after 8-week treatment(P0.01).After 8-week treatment,HAMD scores in trial group were significantly lower than those in control group,and SF-36 scores(vitality,emotional role and mental health) were significantly higher than those in control group(P0.01).There was no statistical difference in ADRs and the TESS scores between two groups(P0.05).Most ADRs were mild and moderate.Conclusion: Paroxetine combined with CXM is more effectiveness and can significantly improve quality of life in patients with depression,and the ADRs rate has no difference compared with placebo control group.