Abstract
BackgroundThis study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted.MethodsPatients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect.ResultsIt was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29).ConclusionsIt was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar.Trial registrationThis clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.
Highlights
Ozone therapy is a modern, non-medicated alternative to control post-operative complications [1]
The application of ozone in Dentistry is based on its antimicrobial properties against gram positive and negative bacteria, viruses and fungi [3]; based on cellular biological characteristics in terms of biocompatibility for oral application [4]
There is a gap about the effect of the trans-operative irrigation solution on the post-operative discomfort management. In light of these findings, the objective of this study was to evaluate the effect of ozonized double-distilled water compared to double-distilled water, as irrigation methods, on the postoperative pain, oedema and trismus after third molar surgery
Summary
Ozone therapy is a modern, non-medicated alternative to control post-operative complications [1]. The antibacterial properties of ozone, as well as its efficacy in the treatment of infection, and hemodynamic and anti-inflammatory properties have been demonstrated [2]. The advantages of this treatment are: simplicity of execution, good tolerance of patients, absence of side effects or adverse reactions and high medical-social efficiency [1]. Ozonized water applied daily may accelerate the epithelial healing of the oral cavity, especially on the first two post-operative days [5]. Ozonized water (0.5–4 μg / mL) was highly effective in killing gram positive and negative microorganisms present in the dental biofilm, in addition to inhibiting the accumulation of experimental plaques in vitro [6].
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