Abstract
Ovariotomy in 8 week-old, specific pathogen free ICR/JCL mice was effective in securing a marked thymus regeneration following a single whole body irradiation with 300 rads of X-ray. Recovery of the bone marrow cell counts, especially of the lymphoid cells, preceded the thymus regeneration and was more marked in spayed mice than in the sham-operated. On the basis of these results, it is suggested that ovarian hormones play a role in the thymic lymphopoiesis by affecting the dynamics of the lymphoid stem cells in the bone marrow and/or the lymphopoietic microenvironments in the thymic cortex.
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