Influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease

Noala Vicensoto Moreira Milhan,Yasmin Rodarte Carvalho,Lilibeth Ferraz De Brito Penna Forte,Ivan Balducci,Luana Marotta Reis De Vasconcelos

doi:10.1590/1677-3225v13n1a10

Noala Vicensoto Moreira Milhan, Yasmin Rodarte Carvalho + Show 3 more

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https://doi.org/10.1590/1677-3225v13n1a10

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Abstract

Aim: To evaluate the influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease induced in rats. Methods: Forty rats were bilaterally ovariectomized and 40 were submitted to sham ovariectomy. Periodontal disease was induced in the mandibular left first molar and the maxillary left first molar was extracted from half of the rats. The rats were randomly euthanized at 3, 7, 14 and 30 days post periodontal disease induction. Serial sections were obtained from the furcation area and stained for histological and histomorphometric analysis. The results of the histomorphometric analysis were statistically analyzed by ANOVA and Tukey tests. Results: The results demonstrated statistically significant differences in the percentage of bone tissue when the variables presence or absence of estrogen (p=0.020) and time of euthanasia (p=0.002) were evaluated. However, the extraction procedure did not significantly affect the percentage of bone tissue (p=0.598). Conclusions: The bone loss resulting from periodontal disease is increased by estrogen deficiency and varies according to the time course of periodontitis. In contrast, masticatory force does not seem to interfere in bone loss derived from periodontal disease.

Highlights

IntroductionOsteoporosis is a progressive systemic disease that reduces, per unit volume, typically mineralized bone and degrades its microstructure
Received for publication: January 15, 2014 Accepted: March 17, 2014Correspondence to: Noala Vicensoto Moreira MilhanDepartamento de Biociência e Diagnóstico Bucal – Universidade Estadual Paulista (UNESP)Osteoporosis is a progressive systemic disease that reduces, per unit volume, typically mineralized bone and degrades its microstructure
The purpose of this study was to evaluate the influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease induced in rats

Summary

Introduction

Osteoporosis is a progressive systemic disease that reduces, per unit volume, typically mineralized bone and degrades its microstructure. These factors increase significantly the bone fragility, leading to increased susceptibility to fractures[1,2,3]. Osteoporosis and periodontal disease have several common risk factors[6], including environmental, genetic, dietary and systemic factors[7] Examples of this are higher prevalence with advancing age[8], negative impacts of smoking on the development and severity of the disease[8,9] and deterioration of tissue repair as a result of the disease. These conditions, whether acquired, congenital or hereditary, can modulate the inflammatory response and promote greater individual susceptibility

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