Abstract
Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.
Highlights
Myopia is a prevalent condition in Asia and a major risk factor for glaucoma and various forms of progressive maculopathy[1,2,3,4,5,6,7,8]
Disc-fovea distance has a significant inter—individual variability in healthy myopic eyes and is significantly associated with macular thickness
It has been reported that a greater disc-fovea distance (DFD) is associated with a longer axial length[26]
Summary
Myopia is a prevalent condition in Asia and a major risk factor for glaucoma and various forms of progressive maculopathy[1,2,3,4,5,6,7,8]. While macular thickness measurements with OCT are useful to detect glaucoma and myopia associated maculopathy, significant variation of macular thickness in healthy individuals has confounded the detection of macular pathologies[13,14,15,16,17,18,19,20,21,22,23,24,25]. Myopic eyes are likely to have a large DFD; the elongation of the eyeball may stretch the fovea further away from the optic disc center[26]. The objective of this study was to determine the influence of DFD on macular thickness For this purpose, we performed spectral-domain OCT measurements in healthy myopic eyes
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