Influence of nutritional state on leptin effects in rats

Abstract

Event Abstract Back to Event Influence of nutritional state on leptin effects in rats Miklos Szekely1*, Marta Balasko1, Tore Schjottelvik1, Szilvia Soos1 and Erika Petervari1 1 University of Pécs, Department of Pathophysiology and Gerontology, Hungary The main target of white adipose tissue-derived leptin is the arcuate nucleus: it inhibits the expression or production of anorexigenic peptides and stimulates the activity of orexigenic ones. Lack of leptin or presence of defective leptin-receptor is accompanied by severe obesity. With aging a decreased responsiveness to leptin develops, which might be connected with age-related obesity. It is also possible, however, that the obesity is responsible for the decreased responsiveness. In the present studies the effect of a 7-day-long, 1 µg/h dose intracerebroventricular infusion of recombinant leptin was studied on body weight (BW) and food intake (FI) in 2- or 6-months-old normally fed (NF2 or NF6; 282±15 or 456±13 g) male Wistar rats and 6-months-old rats made obese by calorie-rich food (OB6; 588±12 g) or 6-months-old calorie-restricted (CR6; 361±7 g) rats (2/3 of normal diet = 16 g/day). By the end of the infusion period BW decreased by 8.6% in NF2, 10.2% in NF6, 5.6% in OB6 and 0.1% in CR rats. FI decreased by ca. 50% in the NF groups, 7.6% in OB6 rats, while CR6 rats ate all the 16 g of food. It is concluded that obesity rather than age contributes to the decreased leptin responsiveness. In later ages this may be even more pronounced. In contrast, in CR6 animals leptin had no effect on FI: this might be due to low responsiveness to anorexigenic peptides (as we have earlier demonstrated for melanocortins in lean juvenile rats) or enhanced responsiveness to orexigenic ones. (Support: OTKA 49321). Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Homeostatic regulatory mechanisms Citation: Szekely M, Balasko M, Schjottelvik T, Soos S and Petervari E (2009). Influence of nutritional state on leptin effects in rats. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.002 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Feb 2009; Published Online: 24 Feb 2009. * Correspondence: Miklos Szekely, University of Pécs, Department of Pathophysiology and Gerontology, Pecs, Hungary, miklos.szekely@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Miklos Szekely Marta Balasko Tore Schjottelvik Szilvia Soos Erika Petervari Google Miklos Szekely Marta Balasko Tore Schjottelvik Szilvia Soos Erika Petervari Google Scholar Miklos Szekely Marta Balasko Tore Schjottelvik Szilvia Soos Erika Petervari PubMed Miklos Szekely Marta Balasko Tore Schjottelvik Szilvia Soos Erika Petervari Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.