Abstract
High oral doses of the anti-inflammatory drugs indomethacin, acetylsalicyclic acid, sodium salicylate, salicylamide, mefenamic acid, flufenamic acid, amidopyrine, phenylbutazone and benzydamine administered repeatedly, did not influence tryptophan pyrrolase activity in livers of intact rats. The nonresponsiveness of tryptophan pyrrolase was in contrast to a stimulation of tyrosine aminotransferase caused by flufenamic acid. Induction of tryptophan pyrrolase due to hydrocortisone was not inhibited generally by non-steroid drugs; exceptions were flufenamic acid and benzydamine which depressed hormonal induction. The authors' recent statement is confirmed that inhibition of protein synthesis due to induction is no essential property of non-steroid antiinflammatory drugs. The immunosuppressive drugs cyclophosphamide, triaziquone and azathioprine increased tryptophan pyrrolase activity, probably due to an inhibition of enzyme degradation; chloroquine, 6-mercaptopurin, 6-azauridin and amethopterin did not influence enzyme activity. Induction of tryptophan pyrrolase due to hydrocortisone was depressed by azathioprine, 6-mercaptopurin, 6-azauridin and amethopterin.
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