Abstract
Nitrous acid alters buoyant density, antibody-combining capacity of D-antigen, chromatographical behaviour to aluminiumhydroxide and sensitivity to RNase at the same rate. These events follow a zero order kinetic indicating a multihit reaction. They occur sometimes after the inactivation of infectivity and indicate a sudden disruption of virus particles whereby high molecular RNA is released. Till the moment of disruption the D-antigenicity of a single virus particle as determined chromatographically is not significantly altered by nitrous acid nor the strain specific elution property of the virus strain used. Results further prove that loss of D-antigenicity during the inactivation process of poliovirus by nitrous acid is caused by a disruption of the particle structure rather then by chemical alterations of the D-antigen on otherwise intact particles.
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