Abstract
home Acta Veterinaria Brno Journal of the University of Veterinary Sciences Brno, Czech Republic Search:
Highlights
Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are cleft by plasma esterases were tested
The arteria carotis was connected by a cannula to the machine HSE UNIPER UP – 100, a universal perfusion system for isolated organs recording and converting actual values of blood pressure into graphical representation in a computer
Systolic blood pressure values after placebo administration Immediately after placebo administration there was a mild decrease of blood pressure, which was most expressive in the 0.5 min after administration – 96% of the initial value
Summary
Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are cleft by plasma esterases were tested. The systolic blood pressure values after 42Bu, 43Bu, 44Bu administration were compared to those of the placebo Group. Significant decrease of systolic blood pressure began immediately after administration of all three tested substances. The ultrashort-acting beta blockers are parenteral agents that can be rapidly titrated in clinical situations where immediate beta adrenergic blockade is warranted (Frishman et al 1998). Their efficacy has been shown in specific clinical settings, e.g. in patients with unstable angina, myocardial infarction, atrial fibrillation or flutter and supraventricular tachycardia (Barbier et al 1995).
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