Abstract
Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 [...]
Highlights
The neuropeptide Y (NPY) is a small peptide with 36 amino acids and is one of the most abundant neurotransmitters of the central and peripheral nervous system.[1]
The NPY c.20T>C variant appears to contribute to the development of Acute Coronary Syndrome (ACS)
The NPY 2 receptor (NPY2R) c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension
Summary
The neuropeptide Y (NPY) is a small peptide with 36 amino acids and is one of the most abundant neurotransmitters of the central and peripheral nervous system.[1] It induces proliferation of vascular smooth muscle cells in humans, promoting the formation and development of new blood vessels.[2] As a result, current research is focused on developing a drug delivery mechanism for NPY to prolong the therapy of diabetic cardiomyopathy and ischemic heart disease without significant systemic consequences.[3] In mammals, NPY. Manuscript received on February 17, 2021; reviewed on July 19, 2021; accepted on September 20, 2021. The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS)
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