Abstract
Three experiments were performed to assess the actions of neonatal injections of α-MSH on later behavioral testing. Experiment 1 investigated the effects of neonatal injections of α-MSH on juvenile rats' ability to learn a differential reinforcement of low rates 20 see schedule of reinforcement. The results indicated that the early treatment improved the animals' ability to respond efficiently for reinforcement. Experiment 2 assessed the effects of neonatal and adult injections of α-MSH on adult rats' ability to acquire and extinguish a two-way active avoidance response. The results indicated that treatment with α-MSH facilitated both acquisition and extinction processes. Experiment 3 studied the actions of neonatal injections of α-MSH on adult male and female rats' ability to learn a discrimination problem followed by learning a reversal problem and an extradimensional shift. The results indicated that early treatment improved performance on all three tasks for males but not females. These results were discussed in view of the methodological and procedural implications they suggested for further exploration of the actions of neuropeptides on behavior.
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