Abstract
Background: Suppression of nonsense mutations using stop codon readthrough drugs is one of the promising treatments for various genetic disorders, including Duchenne muscular dystrophy. However, recent studies indicate that some functional proteins are produced by canonical stop codon readthrough in physiological conditions of human and other animals. Large myelin protein zero (L-MPZ) is one of these proteins. It contains extra 63 amino acids at C-terminus of myelin protein zero (P0), which is a major myelin protein in the peripheral nervous system. Adhesion activity of L-MPZ is less than that of P0, suggesting that the ratio of these two proteins in myelin is important for normal myelin structure and function.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
