Influence of multiple bedside radiation on the lung of preterm SD rats

Abstract

Objective To investigate the effect of multiple bedside radiation on oxygen free radical in neonatal lung tissue.Methods SD rats,on the 21st day of pregnancy,were induced to preterm delivery by frequent movement.And the premature pups were randomly divided to experiment group,who received clinical X-ray once a day,and control group without.Four hours after receiving radiography for 2,4,6,8 and 10 times,10 rats from the experimental group and 5 to 6 rats from the control group were sacrificed.The morphological examination was performed,malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were detected in the lung tissue.Results The consecutive radiography did not affect the lung weight,body weight and lung morphology of premature rats.MDA peaked to (24.45 ±8.30) nmol/mg after the 8th radiography,the activity of SOD increased to (16.26±3.84) nU/mg at the end of the experiment.Compared with the control group,more than six times radiography significantly increased MDA and SOD level (P<0.05).Conelusions Consecutive radiography may have dose cumulative effects on premature SD rats.More than six times bedside X-ray could stimulate the oxidation and antioxidant system of the body. Key words: Radiography; Radiation dosage; Infant,premature; Lung; Superoxide dismutase; Malondialdehyde