Abstract
Because of the advantages of painless and minimally invasion, it has attracted more attention. The microneedle piercing the skin's stratum corneum to deliver drugs into the skin is considered as the optimal choice. The research and development on penetration skin are reviewed. The influence factors of piecing skin are discussed including Needle insertion phases, Piecing force during insertion and microneedle geometry. The interaction between microneedles and skin is affected by many parameters including needle geometry, tissue characteristics and insertional methods. The microneedle geometry is considered as one of the main factor of affecting whether the skin can be penetrated effectively or not.
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