Abstract
The article contains the research results of the effect of cadmium chloride on the indexes of enzyme and nonenzyme systems of antioxidant defense system in young cattle, such as the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels of vitamins A and E. It is established that feeding calves at a dose of toxicant 0.04 mg / kg activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels of vitamins A and E in the blood of experimental animals decreased throughout the experiment. The lowest indicators of antioxidant in the blood of young cattle is set on the twenty -fourth day of the experiment, which is associated with increased activation of lipid peroxidation and the balance between antioxidant system and lipid peroxidation intensity. Given the cadmium load of young cattle it is used a new integrated drug with antioxidant action «Metisevit», which includes metifen, sodium selenite and vitamin E wich is founded as stimulating effects on the activity of antioxidant protection. In particular,it is established probable increase in activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels, vitamin A and vitamin E in the blood of young cattle, which has performed cadmium stress. These changes occur through comprehensive action components of the drug «Metisevit» that leads to the normalization of metabolic processes and free radical in the body of the bull. The results of the research indicate antioxidant drug «Metisevit» in the application of its young cattle and the validity of his administration to improve the body's antioxidant status of chronic cadmium toxicosis.
Highlights
Due to the intensive development of science and technology progress over the past decades the number of chemical compounds to which human and animal contact has increased significantly
With a large number of antioxidants in cadmium toxicosis bull, we studied the «Metisevit» prophylactic effect
When feeding bulls with cadmium chloride at a dose of 0.04 mg/kg body weight and level indicators of nonenzyme and enzyme systems of antioxidant defense in the blood of experimental bulls decreased throughout the experiment
Summary
Due to the intensive development of science and technology progress over the past decades the number of chemical compounds to which human and animal contact has increased significantly. Toxic liver cadmium damages are accompanied by significant flow disturbances oxidative reactions that are characterized by some researches as «oxidative stress» (Honskyy et al, 2001; Gutyj, 2013). Having established that during cadmium toxicity occurs enhance lipid peroxidation (Gutyj, 2013; Gutyj, 2015), we concluded that the action of cadmium to suppress excessive free radical reactions in animals, it is necessary to use drugs with a strong antioxidant effect that can inhibit processes of peroxidate oxidation of lipids. With a large number of antioxidants in cadmium toxicosis bull, we studied the «Metisevit» prophylactic effect. This drug blocks the free radicals and prevents the development of oxidation stress in animals
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