Abstract
The aim of the study was to evaluate the labeling yield of 44Sc-DOTATATE radiobioconjugate when the labeling is performed in the presence of various amounts of competing metallic impurities. In the case of Ca2+ and Al3+ the effect is irrelevant, which is understandable considering the low stability constant of Ca2+-DOTA and Al3+-DOTA complexes. However, the presence of Fe2+/3+, Zn2+ and Cu2+ cations very strongly influences the efficiency of the 44Sc-DOTATATE formation. Surprisingly, while the Zn2+-DOTA stability constants is the smallest, Zn2+ cations competes more strongly with Sc3+ than Fe2+,3+ and Cu2+ at the DOTATATE coordination site.
Highlights
The use of 68Ga labeled peptide in positron emission tomography (PET and PET/CT) to visualize various type of tumors allows better planning of the therapeutic strategy and effective prediction of the treatment outcomes [1]
For example DOTATOC labeled with 68Ga shows high binding affinity for the human somatostatin receptor subtype 2, improving this way tumor imaging capabilities and offering the possibility of low dose imaging, followed by higher dose treatment by DOTATOC labeled with 177Lu or 90Y [2]
The separation process was completed within 50 min from the end of bombardment (EOB) and involved the following steps: dissolution of target, alkalization with NH3, Fig. 2 Influence of DOTATATE concentration on its labeling with 44Sc
Summary
The use of 68Ga labeled peptide in positron emission tomography (PET and PET/CT) to visualize various type of tumors allows better planning of the therapeutic strategy and effective prediction of the treatment outcomes [1]. For example DOTATOC labeled with 68Ga shows high binding affinity for the human somatostatin receptor subtype 2, improving this way tumor imaging capabilities and offering the possibility of low dose imaging, followed by higher dose treatment by DOTATOC labeled with 177Lu or 90Y [2]. Because of their short half-life (T1/2 = 67.71 min), 68Ga-based radiopharmaceuticals are synthesized and used in-house. The relatively high cost of the generators render this isotope of limited utility in a clinical setting These circumstances lead to high overall cost and render 68Ga radiopharmaceuticals of limited interest for centralized production and commercial distribution.
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