Influence of Metabolic Syndrome on Vibration Perception Threshold in First-Degree Relatives of Type 2 Diabetes Mellitus

Lili Yang,Fangping Li,Peng Yun,Xuemei Yu,Zhen Zhang,Dan Liu

doi:10.4236/ym.2021.51005

Abstract

Objectives: To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. Material and Methods: First-degree relatives of type 2 diabetes at the age of 40 - 60 s who had not been diagnosed with diabetes before were enrolled. Height, weight, waist circumference, hip circumference, blood pressure (systolic and diastolic blood pressure), body fat percentage, fasting plasma lipid, fasting plasma glucose, 2-hour blood glucose after 75 g oral glucose and vibration perception threshold were measured. Results: 58 subjects were diagnosed with the level of vibration perception threshold ≥ 16 V. Vibration perception threshold in the metabolic syndrome group was significantly higher than that in the non-metabolic syndrome group (P p P < 0.05). Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose. Stepwise multiple regression analysis showed that there was a positive correlation between waist circumference, systolic blood pressure and vibration perception threshold. Conclusion: Some first-degree relatives of type 2 diabetes who have not been diagnosed with diabetes have high risk of peripheral neuropathy, especially those with metabolic syndrome. Waist circumference and blood pressure are the main factors affecting Vibration perception threshold levels. Early detection of vibration perception threshold should be performed in first-degree relatives of type 2 diabetes with metabolic syndrome. Waist circumference and blood pressure may be important risk factors of peripheral neuropathy for them.

Highlights

Peripheral neuropathy (PN) is a common complication of diabetes whose onset is always insidious
Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose
The vibration perception threshold (VPT) in lower extremity is a sensitive predictor of distal symmetric peripheral neuropathy, whose sensitivity and specificity are high, and its sensitivity increases with age [1]

Summary

Introduction

Peripheral neuropathy (PN) is a common complication of diabetes whose onset is always insidious. Abnormal lipid metabolism is an independent risk factor and is closely related to oxidative stress, insulin resistance, and hyperuricemia [2]. The population of FDRs is larger, who are more prone to metabolic disorders, and always with dyslipidemia, hyperuricemia, insulin resistance, and blood glucose fluctuations have not diagnosed with Diabetes. As far as we know, the occurrence of peripheral neuropathy is related to many factors. Whether there is VPT abnormality in FDR not diagnosed with diabetes before, and what may affect VPT, there are few studies in the past. This study is to investigate the VPT status and its influencing factors of FDR

Objectives

Methods

Results

Conclusion