Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia.

Katarzyna Grzesiak,Marcin Słojewski,Ewa Stachowska,Maria Laszczyńska,Olimpia Sipak,Iwona Rotter,Kinga Walczakiewicz,Aleksandra Rył,Weronika Ratajczak

doi:10.18632/aging.101850

Abstract

The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. The patients differed in terms of hormone levels, but only the differences in SHBG and IGF-1 levels were statistically significant. Analysis of the levels of polysaturated fatty acids in BPH patients showed that MetS contributed to changes in the levels of these acids. We also analyzed the relationship between the levels of fatty acids and diagnostic parameters for MetS. Particular abnormalities were associated with single changes in the levels of fatty acids. In the diabetic patients, changes in the levels of pentadecanoic acid, heptadecanoic acid and cis-11-eicosenoic acid were demonstrated. Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH.

Highlights

Benign prostatic hyperplasia (BPH) belongs to the most common urological diseases afflicting men over 50 years of age [1]
Analysis of the levels of polysaturated fatty acids in benign prostatic hyperplasia (BPH) patients showed that metabolic syndrome (MetS) contributed to changes in the levels of these acids
Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH

Summary

Introduction

Benign prostatic hyperplasia (BPH) belongs to the most common urological diseases afflicting men over 50 years of age [1]. Since interleukin 8 (IL-8) is secreted in the body’s response to changes in the level of oxidation of low density lipoprotein (LDL) and changes in insulin levels, decreased levels of high density lipoprotein (HDL) and www.aging-us.com increased levels of triglycerides (TG), observed in MetS, are significantly associated with inflammation of the prostate gland [8]. These factors may suggest the connection between the processes underlying the development of MetS and BPH-related inflammation [9, 10]

Methods

Results

Conclusion