Abstract
An analysis of evolutionary constraints, gene duplication and essentiability in the yeast metabolic network demonstrates that the structure and function of a metabolic network shapes the evolution of its enzymes.
Highlights
Most studies of molecular evolution are focused on individual genes and proteins
Molecular networks and the genes encoding their building blocks represent two different levels of biological organization that interact in evolution
Cellular metabolic networks are relatively well-characterized in several model organisms such as Saccharomyces cerevisiae [9,10] and Escherichia coli [11]
Summary
Most studies of molecular evolution are focused on individual genes and proteins. understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks, where several previous studies investigated the molecular evolution of proteins, metabolic networks have a relatively well-defined global function. Cellular metabolic networks are relatively well-characterized in several model organisms such as Saccharomyces cerevisiae [9,10] and Escherichia coli [11]. Their function - biosynthesis and energy production - is well understood, as is the relationship of network structure to network function
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