Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension

Abstract

Relevance.Diastolic chronic heart failure (CHF) is a characteristic complication of essential hypertension (EH).
 Materials and methods.62 females with EH were examined. The first group (n=47, mean age 51.56.2 years) persons with EH complicated by diastolic CHF, the second group (n=15, 49.86.7 years) persons with uncomplicated EH. The diagnosis of CHF in females of the first group is confirmed by the data of the test with 6-minute walking, increased blood content of the N-terminal precursor of the brain natriuretic peptide, the presence of left atrial dilatation, hypertrophy and disturbed left ventricle (LV) relaxation. The levels of indices of lipid, carbohydrate, purine metabolism, mediators of systemic inflammation (С-reactive protein), tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6) were studied and a correlation analysis of the whole set of laboratory data with 6-minute walking test results and an integral index of diastolic LV dysfunction (E/e).
 Results. Females with EH complicated initial manifestations of diastolic heart failure, characterized by significantly higher, but the corresponding values of the reference range, the content in blood TNF-a, IL-6 compared with females with uncomplicated EH. In females with hypertension complicated initial manifestations of diastolic heart failure is established significant correlation between blood levels of atherogenic lipids and lipoproteins, glucose, uric acid, CRP, TNF-a, IL-6 on the one hand and indices characterizing reduced tolerance to physical load, diastolic LV dysfunction.
 Conclusion.Formation of diastolic heart failure clinical syndrome as well as disturbances of LV relax function in hypertensive females allows participation of metabolic factors and pro-inflammatory pattern.