Abstract
The influence of mechanical treatment on the properties of betulin, betulin diacetate, and their mixture with water-soluble polymers was studied. It was shown that mechanical treatment in a planetary mill-activator disordered the crystalline structure of betulin and betulin diacetate. Composites of betulin with polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG) that gave an increased betulin concentration upon dissolution in water were prepared. It was shown that H-bonds formed between betulin and PVP upon mechanical activation of their mixtures.
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