Abstract
The influence of mass transfer limitations on the enantio- and regioselectivity in hydrogenation of 1-phenyl-1,2-propanedione was studied. Gas–liquid mass transfer limitation as well as liquid–solid mass transfer limitation did not influence the enantio- and regioselectivity of the reaction, compared to the performance of the system under kinetic control. Under various regimes, the enantiomeric excess of the ( R)-1-hydroxy-1-phenylpropanone was about 55% and regioselectivity remained at about 10, which makes process scale-up with respect to enantio- and regioselectivity straightforward.
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